Study M861
Study name | Brydges CR 2021 |
Title | Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature |
Overall design | The aim of this study was to explore whether indoles are associated with symptoms of depression and anxiety. Serum samples (baseline, 12 weeks) were drawn from participants (n = 196) randomized to treatment with cognitive behavioral therapy (CBT), escitalopram, or duloxetine for major depressive disorder (MDD). Treatment was provided for 12 weeks with medication (medication group, duloxetine 30-60 mg/day or escitalopram 10-20 mg/day) or CBT (CBT group, 16 individual 1-h sessions). A total of 196 patients with MDD had metabolomic measures available for analysis at baseline and 124 were available at week 12. The CBT group included 34 patients, and the medication group included 90 patients (n = 44 duloxetine; n = 46 escitalopram). Remitter was defined as HAM-D score no more than 7 at week 12 (remitter group). |
Study Type | Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 15 |
Sample size | 196 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Brydges CR, Fiehn O, Mayberg HS, et al. Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature. Sci Rep. 2021 Oct 25;11(1):21011. |
Metabolite | Indole-3-propionic acid; Indolelactic acid; Indoleacetic acid/Indole-3-propionic acid ratio; Indoleacetic acid/Indoxyl sulfate ratio; |
