Study M859
Study name | Xu D 2021 |
Title | Intranasal co-delivery of berberine and evodiamine by self-assembled thermosensitive in-situ hydrogels for improving depressive disorder |
Overall design | In this study, a self-assembled thermosensitive in-situ hydrogel is prepared and characterized as a novel co-delivery system. The antidepressant-like effects of the hydrogel are investigated using reserpine-induced model, and the antidepressant mechanism is analyzed by omics methods. Sprague-Dawley rats were divided into the following 3 groups: (1) reserpine group, (2) reserpine + solution group (reserpine plus berberine 12 mg/kg and evodiamine 2 mg/kg; intragastric administration), and (3) reserpine + hydrogel group (reserpine plus berberine 0.05 mg/kg and evodiamine 0.008 mg/kg; intranasal delivery). Rats were injected with reserpine (1.5 mg/kg) after 3 h administration. Hippocampal samples were used for metabonomic analysis. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 10 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Shimadzu LC-20AD Qtrap 5500 tandem mass spectrum (SCIEX, United States); |
PMID | |
DOI | |
Citation | Xu D, Qiu C, Wang Y, et al. Intranasal co-delivery of berberine and evodiamine by self-assembled thermosensitive in-situ hydrogels for improving depressive disorder. Int J Pharm. 2021 Jun 15;603:120667. |
Metabolite |
