Study M855
Study name | Lv SH 2022 |
Title | Correlations between facial emotion processing and biochemical abnormalities in untreated adolescent patients with major depressive disorder: a proton magnetic resonance spectroscopy study |
Overall design | The aim of this study was to test whether adolescents suffering from major depressive disorder (MDD) showed specific alterations in emotional processing and biochemical levels in the fronto-striato-thalamic-cerebellar circuit, compared to age- and gender-matched healthy controls. Thirty-seven adolescent patients with MDD (MDD group) and 30 healthy controls (control group) were recruited. 1H-MRS was used to examine metabolites N-acetyl aspartate and choline-containing compounds in prefrontal cortex, anterior cingulate cortex, putamen, thalamus, and cerebellum. For metabolite quantification, the peak area was normalized by the total phosphorous signal. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-24 >= 20 |
Sample size | 67 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Putamen; Central; Brain; Prefrontal cortex; Central; Brain; Cerebellum; Central; Brain; Thalamus; |
Platform | MRS; MRS: Discovery MR 750 3.0T MRI scanner (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Lv S, Zhong S, Zhang S, et al. Correlations between facial emotion processing and biochemical abnormalities in untreated adolescent patients with major depressive disorder: a proton magnetic resonance spectroscopy study. J Affect Disord. 2022 Jan 1;296:408-417. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
