Study M853
Study name | Linghu T 2021b |
Title | Discovery of biomarkers for depressed patients and evaluation of Xiaoyaosan efficacy based on liquid chromatography-mass spectrometry |
Overall design | In this study, the authors analyzed the plasma of healthy subjects and depressed subjects before and after the treatment with Xiaoyaosan through LC-MS to discover, screen and evaluate the biomarkers for depression. The plasma profiling of depressed patients (depression group, n = 32) before and after 8-week treatment with Xiaoyaosan as well as healthy controls (control group, n = 32) were analyzed through liquid chromatography-mass spectrometry (LC-MS). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Not reported |
Sample size | 64 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Thermo DIONEX UltiMate 3000 High Performance Liquid Chromatography system (Thermo Fisher Scientific, Inc., Germany) with Thermo Q Exactive HF Hybrid Quadrupole-Orbitrap Mass Spectrometer; |
PMID | |
DOI | |
Citation | Linghu T, Liu C, Wang Q, et al. Discovery of biomarkers for depressed patients and evaluation of Xiaoyaosan efficacy based on liquid chromatography-mass spectrometry. Journal of Liquid Chromatography & Related Technologies. 2021. |
Metabolite |
