Study M848
Study name | Yang HL 2021 |
Title | Links between gut dysbiosis and neurotransmitter disturbance in chronic restraint stress-induced depressive behaviours: the role of inflammation |
Overall design | The aim of this study was to investigate the neuroinfammatory reactions in chronic restraint stress (CRS)-induced depression and to delineate the potential links between the gut microbiota and neurotransmitter metabolism. C57BL/6 J mice were divided into the following 3 groups: (1) control group, (2) CRS group, and (3) CRS + dexamethasone group (CRS plus dexamethasone treatment at the dose of 1 mg/kg). The CRS stress procedure lasted for 5 weeks, and dexamethasone was intraperitoneally injected once per day during the model building period. Neurotransmitters levels in serum were detected using ultra-high-performance liquid chromatography-mass spectrometry (n = 5-8 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 J mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 21 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: ultra-high-performance liquid chromatography with Q Exactive hybrid quadrupole-orbitrap mass spectrometer (Thermo Fisher Scientifc, Bremen, Germany); |
PMID | |
DOI | |
Citation | Yang HL, Li MM, Zhou MF, et al. Links between gut dysbiosis and neurotransmitter disturbance in chronic restraint stress-induced depressive behaviours: the role of inflammation. Inflammation. 2021 Oct 17. |
Metabolite |
