Study M845
Study name | Tian PJ 2021b |
Title | Consumption of butylated starch alleviates the chronic restraint stress-induced neurobehavioral and gut barrier deficits through reshaping the gut microbiota |
Overall design | The aim of this study was to investigate the neurobehavioral, immunological, and microbial effects of the short-chain fatty acid (SCFA)-acylated starches in the chronic restraint stress (CRS) model of depression. Mice were divided into the following 5 groups: (1) control group (no stress with normal starch diet), (2) CRS group (CRS stress with normal starch diet), (3) CRS + acylated starch group (CRS stress plus acylated starch diet), (4) CRS + butylated starch group (CRS stress plus butylated starch diet), and (5) CRS + isobutyrylated starch group (CRS stress plus isobutyrylated starch diet). The CRS stress procedure lasted for 2 weeks. Short-chain fatty acid levels in the fecal samples were determined by GC-MS. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; Mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 40 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: TSQ 9000 GC-MS system (Thermo Scientific); |
PMID | |
DOI | |
Citation | Tian P, Zhu H, Qian X, et al. Consumption of butylated starch alleviates the chronic restraint stress-induced neurobehavioral and gut barrier deficits through reshaping the gut microbiota. Front Immunol. 2021 Sep 17;12:755481. |
Metabolite |
