Study M838
Study name | Karen C 2021 |
Title | Lactobacillus paracasei supplementation prevents early life stress-induced anxiety and depressive-like behavior in maternal separation model-possible involvement of microbiota-gut-brain axis in differential regulation of microRNA124a/132 and glutamate receptors |
Overall design | The aim of this study was to investigate stressful social experience in early life by examining how it can induce alterations in the microbiota-gut-brain axis. Maternal separation (MS) was used to construct the depression model. Wistar rats were divided into the following 6 groups (n = 6 in each group): (1) control group, (2) MS group (maternal separation), (3) MS + stranger group (maternal separation with stranger during separation), (4) Lactobacillus paracasei group (no stress and Lactobacillus paracasei supplementation), (5) MS + Lactobacillus paracasei group (maternal separation, with Lactobacillus paracasei supplementation), and (6) MS + stranger + Lactobacillus paracasei group (maternal separation with stranger during separation, with Lactobacillus paracasei supplementation). Maternal separation was carried out for 3 h from postnatal day (PND)-5 to PND-10, and Lactobacillus paracasei was administered via intragastric once per day from PND-5 to PND-16. Fecal samples were used for metabonomic analysis. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Tail suspension test |
Sample size | 36 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: GCMS-QP2020 (Shimadzu PTE LTD, Asia Pacific, Singapore); |
PMID | |
DOI | |
Citation | Karen C, Shyu DJH, Rajan KE. Lactobacillus paracasei supplementation prevents early life stress-induced anxiety and depressive-like behavior in maternal separation model-possible involvement of microbiota-gut-brain axis in differential regulation of microRNA124a/132 and glutamate receptors. Front Neurosci. 2021 Aug 31;15:719933. |
Metabolite |
