Study M837
Study name | Godfrey KEM 2021 |
Title | Effect of rTMS on GABA and glutamate levels in treatment-resistant depression: an MR spectroscopy study |
Overall design | This study used proton magnetic resonance spectroscopy (H1-MRS) to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on levels of gamma-aminobutyric acid (GABA) and combined glutamate/glutamine measure (Glx). Treatment-resistant, currently depressed individuals participated in a naturalistic open-label study with rTMS treatment administered at 10 Hz and 120% of resting motor threshold to the left dorsolateral prefrontal cortex (DLPFC) for 20 sessions. H1 MRS measures were collected at baseline and after four weeks of daily treatment. GABA and Glx were measured from both the left DLPFC and a control region (right motor cortex). Twenty-seven participants completed the study and were included in the analysis. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | Primary diagnosis of unipolar MDD, MADRS >= 20 |
Sample size | 27 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Motor cortex; |
Platform | MRS; MRS: 3 T Siemens Skyra scanner; |
PMID | |
DOI | |
Citation | Godfrey KEM, Muthukumaraswamy SD, Stinear CM, et al. Effect of rTMS on GABA and glutamate levels in treatment-resistant depression: an MR spectroscopy study. Psychiatry Res Neuroimaging. 2021 Nov 30;317:111377. |
Metabolite |
