Study M836
Study name | Ding Y 2021 |
Title | A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites |
Overall design | The aim of this study was to evaluate the antidepressant effect of Akkermansia muciniphila in a mouse model of depression induced by chronic restraint stress (CRS). C57BL/6 mice were divided into the following 3 groups (n = 6 in each group): (1) control group, (2) CRS group, and (3) CRS + Akkermansia muciniphila group (stress plus Akkermansia muciniphila treatment at the dose of 5 * 10^8 CFU /mL, 200 uL). The CRS stress procedure lasted for 3 weeks, and Akkermansia muciniphila was administered via intragastric during the model building period. Five serum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 15 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: 1290 UHPLC-QE Orbitrap/MS analysis (Agilent Technologies, Hilden, Germany); |
PMID | |
DOI | |
Citation | Ding Y, Bu F, Chen T, et al. A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites. Appl Microbiol Biotechnol. 2021 Nov;105(21-22):8411-8426. |
Metabolite | L-Methionine; Histamine; Anserine; 3-Amino-2-piperidone; Penicillamine; 2-Pyrrolidineacetic acid; Mesalazine; Norsertraline; 2-Aminomucote; Trimethylselenonium; Aminopyrrolnitrin; 2-Pyrocatechuic acid; [Nitrilotris(methylene)]trisphosphonic acid; Salicyluric beta-D-glucuronide; Fosetyl; 4-[2,3-dioxo-3-(2,4,6-trihydroxy-3-methoxyphenyl)propyl]-2-hydroxy-6-methoxyphenyl oxidanesulfonic acid; Methylpyrazine; Edaravone; PC(18:3(9Z,12Z,15Z)/18:1(11Z)); Pyrazoxyfen; 2'',3'',6''-Tris-O-(3,4,5-trihydroxybenzoyl)-3'-Glucosyl-2',4',6'-trihydroxyacetophenone; |
