Study M834
Study name | Yu J 2021 |
Title | Inhibition of CB1 receptor alleviates electroconvulsive shock-induced memory impairment by regulating hippocampal synaptic plasticity in depressive rats |
Overall design | The aim of this study was to clarify whether the endocannabinoid system could be involved in electroconvulsive shock-induced cognitive impairment and might be associated with synaptic plasticity. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. The amount of 2-arachidonoylglycerol in the hippocampus was determined by LC-MS/MS (n = 3 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 6 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: 6470 Triple Quad LC-MS/MS (Agilent Technologies, CA, USA); |
PMID | |
DOI | |
Citation | Yu J, Ren L, Min S, et al. Inhibition of CB1 receptor alleviates electroconvulsive shock-induced memory impairment by regulating hippocampal synaptic plasticity in depressive rats. Psychiatry Res. 2021 Jun;300:113917. |
Metabolite |
