Study M831
Study name | Hirtz R 2021 |
Title | Lack of evidence for a relationship between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axis in adolescent depression |
Overall design | The aim of this study was to investigate the interaction of the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axis in adolescents with major depressive disorder (MDD). Serum levels of cortisol were determined in 273 adolescents diagnosed with MDD (MDD group). Primary data from the norming sample (control group, n = 573) of the cortisol assay used in the present study served as reference for cortisol levels in MDD. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed major depressive disorder |
Sample size | 846 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity with Waters Quattro Premier/Xe triple-quadrupole mass spectrometer (Waters, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Hirtz R, Libuda L, Hinney A, et al. Lack of evidence for a relationship between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axis in adolescent depression. Front Endocrinol. 2021 May 24;12:662243. |
Metabolite |
