Study M830
Study name | Duan LN 2021 |
Title | Metabolomics analysis on mice with depression ameliorated by acupoint catgut embedding |
Overall design | The aim of this study was to investigate the effects and underlying mechanism of acupoint catgut embedding on depression. Acupoint catgut embedding treatment was applied at the Baihui (GV20) and Dazhui (GV14) acupoints of corticosterone-induced depression model mice. Swiss mice were divided into the following 3 groups: (1) control group, (2) corticosterone group, and (3) corticosterone + acupoint catgut embedding group. Corticosterone was subcutaneously injected for 21 consecutive days at a dose of 20 mg/kg. The mice in the acupoint catgut embedding treatment group were treated with acupoint catgut embedding at GV20 and GV14 once on days 8 and 15. The metabolic profiles of brain samples were characterized by LC-MS/MS (n = 6 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; Swiss mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 18 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: Waters 2D UPLC system (Waters Corp., Milford, MA, USA) and Q Exactive tandem mass spectrometer (Thermo Fisher Scientific, USA); |
PMID | |
DOI | |
Citation | Duan L, Qiu W, Bai G, et al. Metabolomics analysis on mice with depression ameliorated by acupoint catgut embedding. Front Psychiatry. 2021 Aug 3;12:703516. |
Metabolite | Glycerol; L-Cysteine; L-Valine; L-Leucine; Glycine; L-Tyrosine; Spermidine; Testosterone; LysoPE(0:0/20:3(5Z,8Z,11Z)); Vitamin A; Hymexazol O-glucoside; Atagabalin; 2,2,6,6-Tetramethyl-4-piperidinone; |
