Study M822
Study name | Parul 2021 |
Title | Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats |
Overall design | The aim of this study was to explore precise mechanism by which chronic unpredictable stress (CUS) induce anxious depression. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUS group. The CUS stress procedure lasted for 4 weeks. Dopamine and serotonin levels in cortex and hippocampus region of brain was measured using LC-MS/MS (n = 4 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, social interaction test, forced swim test |
Sample size | 8 |
Tissue | Central; Brain; Cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: LC-MS/MS (ABSciex 4000, Toronto, Canada); |
PMID | |
DOI | |
Citation | Parul, Mishra A, Singh S, et al. Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. Brain Res Bull. 2021 Jul;172:164-179. |
Metabolite |
