Study M816
Study name | Zhu JP 2021 |
Title | Baihe Jizihuang Tang ameliorates chronic unpredictable mild stress-induced depression-like behavior: integrating network pharmacology and brain-gut axis evaluation |
Overall design | The aim of this study was to clarify the antidepressive effects and molecular mechanism of Baihe Jizihuang Tang in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 5 groups: (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 1.8 mg/kg), (4) CUMS + middle dose of Baihe Jizihuang Tang group (stressor plus Baihe Jizihuang Tang treatment at the dose of 5.4 g/kg), and (5) CUMS + high dose of Baihe Jizihuang Tang group (stressor plus Baihe Jizihuang Tang treatment at the dose of 10.8 g/kg). The CUMS stress procedure lasted for 30 days, and drugs were administered via intragastric once per day during the model building period. Dopamine, norepinephrine, serotonin, and glutamic acid concentrations in the hippocampus were determined by UPLC-MS. Six samples per group were used for targeted metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 30 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: UPLC Coupled with Triple Quadrupole (QQQ)/MS; |
PMID | |
DOI | |
Citation | Zhu J, Wu H, Zi Y, et al. Baihe Jizihuang Tang ameliorates chronic unpredictable mild stress-induced depression-like behavior: integrating network pharmacology and brain-gut axis evaluation. Evid Based Complement Alternat Med 2021;5554363. |
Metabolite |
