Study M813
Study name | Yan L 2021 |
Title | Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice |
Overall design | This study used wild type and Fat-1 mice with or without olfactory bulbectomy to explore whether endogenous n-3 PUFA treatment of depression was through rectifying lipid metabolism, and to discover the possible lipid metabolic pathways. C57BL/6 mice were divided into the following 2 groups (n = 5 in each group): (1) control group, and (2) olfactory bulbectomy group. After surgical procedure, mice were recovered for 21 days. Metabolomic changes in the serum were identified by liquid chromatography-time-of-flight mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 10 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters ACQUITY UPLC system coupled with AB SCIEX Triple TOF 5600 (AB SCIEX, Framingham, USA); |
PMID | |
DOI | |
Citation | Yan L, Gu MQ, Yang ZY, et al. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain Behav Immun. 2021 Aug;96:143-153. |
Metabolite | PC(20:5(5Z,8Z,11Z,14Z,17Z)/P-18:1(11Z)); PC(19:1(9Z)/0:0); PS(18:1(9Z)/22:2(13Z,16Z)); PG(P-18:0/18:4(6Z,9Z,12Z,15Z)); PS(12:0/15:1(9Z)); PE(P-19:1(12Z)/0:0); PS(12:0/14:1(9Z)); PS(12:0/13:0); PS(14:0/16:1(9Z)); PC(18:3(9Z,12Z,15Z)/22:1(13Z)); Glutamyllysine; Hydratopyrrhoxanthinol; (2Z,8S,9Z)-2,9-Heptadecadiene-8-hydroxy-4,6-diyne-1-yl acetate; |
