Study M812

Study name

Wang X 2021

Title

[Magnetic resonance spectroscopy in hippocampus for diagnosis of first-episode depression disorder]

Overall design

The aim of this study was to measure hippocampal metabolite changes of first episode major depressive disorder (MDD) patients. Hippocampal changes in creatine and phosphocreatine (tCr), N-acetyl-aspartate, choline-containing compounds, and myo-inositol were measured in 44 patients with first-episode MDD (MDD group) and 20 normal subjects (control group). Metabolite quantification was reported relative to tCr as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

64

Tissue

Central; Brain; Hippocampus;

Platform

MRS; MRS: Siemens Verio 3.0 T MRI;

PMID

N/A

DOI

10.13929/j.issn.1003-3289.2021.02.007

Citation

Wang X, Hu X, Liu H, et al. [Magnetic resonance spectroscopy in hippocampus for diagnosis of first-episode depression disorder]. Chin J Med Imaging Technol 2021;37(2):189-193. (Article in Chinese)

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;