Study M807
Study name | Luo XR 2021 |
Title | Glutamate chemical exchange saturation transfer imaging and functional alterations of hippocampus in rat depression model: a pilot study |
Overall design | The aim of this study was to study the changes in glutamate chemical exchange saturation transfer (GluCEST) value in the hippocampus of rat model exposed to chronic unpredictable mild stress (CUMS), and to explore the effect of this change on the activity of hippocampal glutamatergic neurons. Sprague-Dawley rats were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 6 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7.0-T animal MRI scanner (70/20 PharmaScan, Bruker Biospin GmbH, Germany); |
PMID | |
DOI | |
Citation | Luo X, Ren Q, Luo M, et al. Glutamate chemical exchange saturation transfer imaging and functional alterations of hippocampus in rat depression model: a pilot study. J Magn Reson Imaging. 2021 Jul 22. |
Metabolite |
