Study M803
Study name | Ermis C 2021 |
Title | Association between anterior cingulate cortex neurochemical profile and clinical remission after electroconvulsive treatment in major depressive disorder: a longitudinal 1H magnetic resonance spectroscopy study |
Overall design | The aim of this study was to assess anterior cingulate cortex (ACC) neurochemical profile of patients with unipolar major depressive disorder (MDD) before and after electroconvulsive therapy (ECT) by using 1H magnetic resonance spectroscopy (1H-MRS). Patients with acute depression receiving bilateral ECT twice weekly for 2 weeks were randomized into 3 intervention groups, namely, early treatment with sertraline, late treatment with sertraline, or placebo. After randomization, all patients were treated with ECT for 2 more weeks to complete a 4-week duration (8 sessions of ECT in total). MADRS scores of 9 or less was used as the criterion of remission after ECT. Among the 30 patients treated with ECT, 16 patients met predefined remission criteria (remitter group), and 14 patients was divided into the nonremitter group. Using 1H-MRS, the metabolite levels of choline, glutamate + glutamine (Glx), myo-inositol, N-acetylaspartate, and total creatine were measured in ACC before and after 4-week ECT. Metabolite levels were measured in institutional units and expressed as absolute values and metabolite/total creatine ratios. |
Study Type | Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, MADRS > 22 |
Sample size | 30 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 1.5 Tesla (Philips Healthcare, Best, the Netherlands); |
PMID | |
DOI | |
Citation | Ermis C, Aydin B, Kucukguclu S, et al. Association between anterior cingulate cortex neurochemical profile and clinical remission after electroconvulsive treatment in major depressive disorder: a longitudinal 1H magnetic resonance spectroscopy study. J ECT. 2021 Apr 9. |
Metabolite |
