Study M801
Study name | Zacharias HU 2021 |
Title | A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression |
Overall design | The aim of this study was to conduct a metabolome-wide association analysis to investigate the link between the serum metabolome and depressed mood in 1411 participants of the KORA F4 study (discovery cohort). Three categories, 'no', 'other', and 'major depressive symptoms' were defined for the KORA F4 discovery cohort if 2-4 or at least 5 of the PHQ-9 questions had been answered with at least 'more than half of the days' in the past two weeks, and one of the diagnosed symptoms was depressed mood or anhedonia. For the KORA F4 study, 72 participants suffering from depressed mood (depression group). Serum metabolomics data comprised 353 unique metabolites measured by Metabolon. The authors found significantly lower laurylcarnitine levels in KORA F4 participants with depressed mood after multiple testing correction according to Benjamini/Hochberg. This finding was replicated in the independent SHIP-Trend study (968 study participants). For the Ship-Trend baseline cohort, 52 participants were diagnosed with depressed mood (depression group). A targeted metabolic profiling approach for the plasma specimens was carried out based on the SHIP-Trend study participants using the AbsoluteIDQ p180 Kit. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | At least 2 of the PHQ-9 questions had been answered with at least “more than half of the days” in the past two weeks |
Sample size | 2379 |
Tissue | Peripheral; Blood; Serum; Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: not reported; MS-based; LC-MS: not reported; MS-based; LC-MS: MAT-95 double-focusing magnetic/electric sector mass spectrometer ultra-high performance liquid chromatography/tandem MS (UHPLC/MS/MS; Thermo Scientific, USA); |
PMID | |
DOI | |
Citation | Zacharias HU, Hertel J, Johar H, et al. A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression. Mol Psychiatry. 2021 Jun 4. |
Metabolite |
