Study M790
Study name | Liu XJ 2021c |
Title | Hepatic metabolomics of the compatibility effect of Xiaoyaosan on CUMS-induced depression based on the TCM theory of "Treating Diseases via Regulating the Liver's Function" |
Overall design | The aim of this study was to demonstrate the scientific connotations and compatibility effects of Xiaoyaosan based on the theory of "Treating Diseases via Regulating the Liver’s Function" by hepatic metabolomics. The chronic unpredictable mild stress (CUMS) depression model was constructed. A 1H NMR-based hepatic metabolomics approach coupled with multivariate data analysis was performed. Sprague-Dawley rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + Xiaoyaosan group (stressor plus Xiaoyaosan treatment at the dose of 46.3 g/kg/day), and (4) CUMS + venlafaxine group (stressor plus venlafaxine treatment at the dose of 35 mg/kg/day). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. Six liver samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Liver; Liver; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu XJ, Liu HL, Zhao D, et al. Hepatic metabolomics of the compatibility effect of Xiaoyaosan on CUMS-induced depression based on the TCM theory of "Treating Diseases via Regulating the Liver's Function". J Pharm Biomed Anal. 2021 Jul 15;201:114123. |
Metabolite | L-Valine; L-Leucine; L-Proline; |
