Study M788
Study name | Linghu T 2021a |
Title | Stable isotope-resolved metabolomics reveals the abnormal brain glucose catabolism in depression based on chronic unpredictable mild stress rats |
Overall design | In this study, the authors applied a comprehensive method for stable isotope-resolved metabolomics to decipher the abnormal brain glucose catabolism in chronic unpredictable mild stress (CUMS) rats. Sprague-Dawley rats were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Ten samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Thermo DIONEX UltiMate 3000 high-performance liquid chromatography coupled with Thermo Q Exactive HF Hybrid Quadrupole-Orbitrap mass spectrometer (Thermo Fisher Scientific Inc., Bremen, Germany); |
PMID | |
DOI | |
Citation | Ling-Hu T, Liu SB, Gao Y, et al. Stable isotope-resolved metabolomics reveals the abnormal brain glucose catabolism in depression based on chronic unpredictable mild stress rats. J Proteome Res. 2021 Jul 2;20(7):3549-3558. |
Metabolite | L-Proline; L-Glutamic acid; L-Lactic acid; L-Alanine; L-Asparagine; L-Glutamine; L-Aspartic acid; Fumaric acid; Pyruvic acid; Inosine; L-Malic acid; DL-O-Phosphoserine; |
