Study M786
Study name | Kurokawa S 2021 |
Title | Fecal microbial and metabolomic change during treatment course for depression: an observational study |
Overall design | The aim of this study was to investigate the relationship between microbial, metabolomic features and the course of treatment for depression in a real-world clinical setting. Patients diagnosed with depressive disorders were divided into three groups: non-responders (non-responder group; having HAM-D > 7 at baseline and not reaching 50% reduction at endpoint; n = 16), responders (responder group; having HAM-D > 7 at baseline, showing a HAM-D reduction of >= 50%, and/or reaching HAM-D <= 7 at endpoint; n = 11), and stable remitters (HAM-D <= 7 at baseline and maintained their remission throughout the longitudinal observation; n = 6). Baseline data were obtained within 10 days of hospitalization; midterm data were obtained from days 14-20; endpoint data were obtained after day 21 until the day of discharge. Gut microbiomes were analyzed using 16S rRNA gene sequencing, and gut metabolomes were analyzed by a mass spectrometry approach. |
Study Type | Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD, HAMD-17 > 7 |
Sample size | 27 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; CE-MS: Agilent capillary electrophoresis system (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Kurokawa S, Tomizawa Y, Miyaho K, et al. Fecal microbial and metabolomic change during treatment course for depression: an observational study. J Psychiatr Res. 2021 Aug;140:45-52. |
Metabolite |
