Study M785

Study name

Kantrowitz JT 2021

Title

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

Overall design

In this study, the authors examined ventromedial prefrontal cortex/anterior cingulate cortex (vmPFC/ACC) Glx (combination of glutamate and glutamine) and glutamate levels using 1H MRS in 34 medication-free, symptomatic, chronically ill major depressive disorder patients (MDD group) and 32 healthy volunteers (control group), and GABA levels in a subsample. Metabolite quantification was reported relative to N-acetyl-L-aspartic acid or total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, MADRS >= 22

Sample size

66

Tissue

Central; Brain; Ventromedial prefrontal cortex;

Platform

MRS; MRS: General Electric SIGNA Premier 3 T MR scanner;

PMID

34354048

DOI

10.1038/s41398-021-01541-1

Citation

Kantrowitz JT, Dong Z, Milak MS, et al. Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder. Transl Psychiatry. 2021 Aug 5;11(1):419.

Metabolite

GABA/(Creatine and Phosphocreatine) ratio;

(Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio;

Glutamate/(Creatine and Phosphocreatine) ratio;

(Glutamate and Glutamine)/N-Acetyl aspartate ratio;

Glutamate/N-Acetyl aspartate ratio;

GABA/N-Acetyl aspartate ratio;