Study M783
Study name | Jiang WX 2021 |
Title | Alteration of gut microbiome and correlated lipid metabolism in post-stroke depression |
Overall design | The aim of this study was to determine whether and how microbial composition and function altered among control, stroke and post-stroke depression rats. After the post-stroke depression rat model was successfully established, gut microbiome combined with fecal metabolome approach were performed to identify potentially PSD-related gut microbes and their functional metabolites. Stroke model was established by transient middle cerebral artery occlusion, then rats were subjected to the 4-week chronic unpredictable mild stress (CUMS) stress. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) stroke group, and (3) stroke + CUMS group. Eight samples per group were used for fecal metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C; |
PMID | |
DOI | |
Citation | Jiang W, Gong L, Liu F, et al. Alteration of gut microbiome and correlated lipid metabolism in post-stroke depression. Front Cell Infect Microbiol. 2021 Apr 22;11:663967. |
Metabolite | L-Glutamic acid; Tyramine; L-Kynurenine; 5-Methoxytryptamine; Maleic acid; N-Acetyl-L-alanine; Cytosine; Phenylacetic acid; Lanosterol; 1,5-Anhydrosorbitol; trans-Ferulic acid; 3-Arylcarbonyl-alanine; Lactobionic acid; Daidzein; Cyanoalanine; Arbutin; Stigmasterol; (+)-Gallocatechin; |
