Study M765
Study name | Liao XX 2021 |
Title | Interaction of serum copper and neurometabolites on executive dysfunction in unmedicated patients with major depressive disorder |
Overall design | The aim of this study was to assess whether the interaction between serum copper levels and neurometabolic alterations is involved in the deficit of executive function in patients with unmedicated major depressive disorder (MDD). In this study, 41 patients (MDD group) and 41 healthy controls (control group) underwent proton magnetic resonance spectroscopy (1H-MRS) to obtain ratios of N-acetyl aspartate to creatine (NAA/Cr) and choline-containing compounds to creatine (Cho/Cr) in the lenticular nucleus of basal ganglia. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 > 20 |
Sample size | 82 |
Tissue | Central; Brain; Lenticular nucleus; |
Platform | MRS; MRS: 3.0 T GE Discovery MR system (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Liao X, Lai S, Zhong S, et al. Interaction of serum copper and neurometabolites on executive dysfunction in unmedicated patients with major depressive disorder. Front Psychiatry. 2021 Mar 3;12:564375. |
Metabolite |
