Study M763

Study name

Harfmann EJ 2020

Title

Circulating endocannabinoid concentrations in grieving adults

Overall design

The aim of this study was to investigate the hypothesis that the endocannabinoid signaling is abnormal in grief, using circulating endocannabinoid concentrations as a biomarker of central endocannabinoid signaling. A predominantly older sample of grief participants, within 13 months following the death of a loved one (grief group, with mean HAMD score of 12.2; n = 44), and healthy comparison participants (control group, n = 17) were studied. Serum concentrations of N-arachidonoylethanolamine and 2-arachidonoylglycerol were determined in extracted lipids from serum samples using stable isotope-dilution, liquid chromatography-mass spectrometry.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom; Depressive symptom;

Criteria for depression

Not reported

Sample size

61

Tissue

Peripheral; Blood; Serum;

Platform

MS-based; LC-MS: not reported;

PMID

32682172

DOI

10.1016/j.psyneuen.2020.104801

Citation

Harfmann EJ, McAuliffe TL, Larson ER, et al. Circulating endocannabinoid concentrations in grieving adults. Psychoneuroendocrinology. 2020 Oct;120:104801.

Metabolite

Anandamide;