Study M762
Study name | Hao Y 2021 |
Title | Metformin attenuates the metabolic disturbance and depression-like behaviors induced by corticosterone and mediates the glucose metabolism pathway |
Overall design | The aim of this study was to investigate metabolism disturbances induced by corticosterone and determine if metformin can reverse these effects and their accompanying depression-like behaviors. Wistar rats were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) corticosterone group, and (3) corticosterone + metformin group (corticosterone plus metformin treatment at the dose of 50 mg/kg). Corticosterone was subcutaneously injected at the dose of 40 mg/kg for 4 weeks. The metabolites in the liver were quantified by LC-MS/MS analysis (n = 7-8 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 22 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC Ultra Performance LC System with 5500 QTRAP mass spectrometer (AB SCIEX); |
PMID | |
DOI | |
Citation | Hao Y, Tong Y, Guo Y, et al. Metformin attenuates the metabolic disturbance and depression-like behaviors induced by corticosterone and mediates the glucose metabolism pathway. Pharmacopsychiatry. 2021 Feb 25. |
Metabolite | Citric acid; L-Lactic acid; Succinic acid; Oxoglutaric acid; Fumaric acid; Glucose 6-phosphate; Pyruvic acid; cis-Aconitic acid; Isocitric acid; Guanosine triphosphate; Dihydroxyacetone phosphate; 3-Phosphoglyceric acid; L-Malic acid; |
