Study M761
Study name | Guan JT 2020 |
Title | Early life stress increases brain glutamate and induces neurobehavioral manifestations in rats |
Overall design | In this study, 7T proton magnetic resonance spectroscopy (7T 1H MRS) was used to detect metabolic glutamate in a rat model to investigate maternal deprivation-induced early life stress. Sprague-Dawley rats were divided into the following 2 groups (n = 15 per group): (1) control group, and (2) maternal deprivation group. During postnatal days 1 to 14 for the maternal deprivation group, pups were separated from their mother for three hours every day. Metabolites in hippocampus and prefrontal cortex were compared using MRS. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 30 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7T animal magnetic resonance imaging machine; |
PMID | |
DOI | |
Citation | Guan J, Ding Y, Rong Y, et al. Early life stress increases brain glutamate and induces neurobehavioral manifestations in rats. ACS Chem Neurosci. 2020 Dec 16;11(24):4169-4178. |
Metabolite |
