Study M755
Study name | Xu K 2021 |
Title | Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice |
Overall design | The aim of this study was to examine the effects of low- and high-dose D-ribose and D-mannose on depressive- and anxiety-like behavior. C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) high-dose D-ribose group (D-ribose daily intraperitoneal injections at the dose of 4 g/kg for 4 weeks). High-dose levels of D-ribose induced depressive-like behavior in mice. Nine hippocampal samples per group were used for targeted metabolomics analysis. |
Study Type | Type1; |
Data available | |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, tail suspension test |
Sample size | 18 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Acquity UPLC I-Class (Waters Corp. Milford, MA) coupled to a Waters Xevo G2-S QTof massmspectrometry system; |
PMID | |
DOI | |
Citation | Xu K, Wang M, Zhou W, et al. Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice. Transl Psychiatry. 2021 Feb 2;11(1):90. |
Metabolite |
