Study M752
Study name | Zhao ZJ 2020 |
Title | Multimodal magnetic resonance imaging and therapeutic intervention with Yi-nao-jie-yu decoction in a rat model of post-stroke depression |
Overall design | The aim of this study was to use the MR techniques to evaluate changes in post-stroke depression (PSD) and Yi-nao-jie-yu decoction-treated rats. The PSD model employed isolation housing in combination with a 3-week chronic unpredictable mild stress (CUMS) paradigm following the middle cerebral artery occlusion (MCAO) operation. Wistar rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) PSD group (MCAO with CUMS stress), (3) PSD + Yi-nao-jie-yu decoction group (MCAO and CUMS stress, with Yi-nao-jie-yu decoction treatment at the dose of 25 mg/kg), and (4) CUMS group (sham MCAO, with CUMS stress). The Nacetyl aspartate/creatine, choline/creatine, glutamate/creatine, and myo-inositol/creatine ratios in the prefrontal cortex and hippocampus were determined using MRS for comparisons between group. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: 7.0-T MRI scanner (Bruker, Germany); |
PMID | |
DOI | |
Citation | Zhao Z, Zhang W, Zhang Y, et al. Multimodal magnetic resonance imaging and therapeutic intervention with Yi-nao-jie-yu decoction in a rat model of post-stroke depression. Front Psychiatry. 2020 Nov 4;11:557423. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
