Study M746

Study name

Spurny B 2021

Title

Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm

Overall design

The aim of this study was to elaborate the effects of associative relearning and selective serotonin reuptake inhibitors (SSRIs) treatment on GABAergic and glutamatergic function within and between five brain regions using magnetic resonance spectroscopy imaging. Healthy subjects were randomized into four groups which underwent three weeks of an associative relearning paradigm, with or without emotional connotation, under SSRI (10 mg escitalopram for 3 weeks) or placebo administration. Magnetic resonance spectroscopy imaging measurements, using a spiral-encoded, 3D-GABA-edited MEGA-LASER sequence at 3T, were performed on the first and last day of relearning. Mean GABA+/tCr and Glx/tCr ratios were quantified for the hippocampus, insula, putamen, pallidum and thalamus. A total of 66 subjects for Glx/tCr and 58 subjects for GABA+/tCr were included in the final analysis.

Study Type

Type3;

Data available

Unavailable

Organism

Human;

Categories of depression

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Not reported

Sample size

66

Tissue

Central; Brain; Hippocampus;

Central; Brain; Insula;

Central; Brain; Putamen;

Central; Brain; Pallidum;

Central; Brain; Thalamus;

Platform

MRS; MRS: 3 Tesla MR Scanner (MAGNETOM Prisma, Siemens Medical, Erlangen, Germany);

PMID

33657450

DOI

10.1016/j.neuroimage.2021.117913

Citation

Spurny B, Vanicek T, Seiger R, et al. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. Neuroimage. 2021 Feb 28;232:117913.

Metabolite

(Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio;