Study M745
Study name | Silberbauer LR 2020 |
Title | Effect of ketamine on limbic GABA and glutamate: a human in vivo multivoxel magnetic resonance spectroscopy study |
Overall design | The aim of this study was to investigate subacute changes in cerebral Glx (glutamate + glutamine), GABA and their ratio in seven brain regions central to ketamine treatment. Twenty-five healthy subjects underwent two multivoxel magnetic resonance spectroscopy (MRS) scans at baseline and 2 h following intravenous administration of racemic ketamine (0.8 mg/kg body weight over 50 min). Automated region-of-interest-based quantification of mean metabolite concentration was used to assess changes in GABA+/total creatine (tCr), Glx/tCr, and GABA+/Glx ratios in the thalamus, hippocampus, insula, putamen, rostral anterior cingulate cortex, caudal anterior cingulate cortex, and posterior cingulate cortex. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 25 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Thalamus; Central; Brain; Insula; Central; Brain; Putamen; Central; Brain; Anterior cingulate cortex; Central; Brain; Posterior cingulate cortex; |
Platform | MRS; MRS: 3 Tesla MR Scanner (MAGNETOM Prisma, Siemens Medical, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Silberbauer LR, Spurny B, Handschuh P, et al. Effect of ketamine on limbic GABA and glutamate: a human in vivo multivoxel magnetic resonance spectroscopy study. Front Psychiatry. 2020 Sep 8;11:549903. |
Metabolite |
