Study M739
Study name | Liu XJ 2021b |
Title | Serum metabolomics reveals compatibility rules of the antidepressant effects of Xiaoyaosan and its efficacy groups |
Overall design | In this study, the chronic unpredictable mild stress (CUMS) depression-like model was constructed. Afterwards, Xiaoyaosan was divided into the Shugan and the Jianpi groups according to the research strategy of efficacy groups. Sprague-Dawley rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stressor plus venlafaxine treatment at the dose of 35 mg/kg), and (4) CUMS + Xiaoyaosan group (stressor plus Xiaoyaosan treatment at the dose of 46.3 g/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. A proton nuclear magnetic resonance spectrometry-based serum metabolomics was applied. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 24 |
Tissue | Peripheral; Blood; Serum; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker, Germany); |
PMID | |
DOI | |
Citation | Liu X, Wang Y, Lv M, et al. Serum metabolomics reveals compatibility rules of the antidepressant effects of Xiaoyaosan and its efficacy groups. Psychiatry Res. 2021 Feb 24;299:113827. |
Metabolite | Glycerol; 3-Hydroxybutyric acid; |
