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Study M737

Study name

Liu T 2020b

Title

Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

Overall design

The aim of this study was to measure gut microbiota alterations and aberrant metabolism in diarrhoea-predominant irritable bowel syndrome (IBS-D) patients with depressive symptoms. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) harvested urinary metabolomic data from 70 IBS-D (IBS-D group) and 42 healthy control (control group) samples. The mean score of the Hamilton Depression Scale was 13.23 for the IBS-D group.

Study Type

Type1;

Data available

https://doi.org/10.6084/m9.figshare.8218889

Organism

Human;

Categories of depression

Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity;

Criteria for depression

Not reported

Sample size

112

Tissue

Peripheral; Urine; Urine;

Platform

MS-based; LC-MS: Ultimate 3000 ultra-high performance liquid chromatography system (Dionex, Sunnyvale, CA, United States) united with Q Exactiv Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo Fisher Scientific, Waltham, MA, United States);

PMID

32552668

DOI

10.1186/s12866-020-01841-4

Citation

Liu T, Gu X, Li LX, et al. Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients. BMC Microbiol. 2020 Jun 17;20(1):168.

Metabolite

2-Furoic acid;

2-Phenylethanol;

1-Methylhistidine;

Quinic acid;

Erythrose;

Epinephrine;

4-Acetamidobutanoic acid;

Dihydrothymine;

Anserine;

D-2-Hydroxyglutaric acid;

5-(2-Hydroxyethyl)-4-methylthiazole;

N-Methylphenylethanolamine;

Tiglylcarnitine;

Phenylacetylglutamine;

8-Amino-7-oxononanoic acid;

Allopurinol;

(2R,3S)-2,3-Dimethylmalic acid;

5-Methoxybenzimidazole;

3,4-Dihydroxyphenylglycol;

2-Oxosuberate;

Lycopsamine;

3,4-Dihydroxymandelaldehyde;

Hexanamide;

Caroxazone;

(1R,2S,3S,4R,6S)-4,6-Diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-xylopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside;

Diethyl fumarate;

Hexamethylene bisacetamide;

(R)-3-((R)-3-Hydroxybutanoyloxy)butanoate;

cis-2-Carboxycyclohexyl-acetic acid;

3-Hydroxy-cis-5-tetradecenoylcarnitine;

(S)-2-Acetolactate;

7-Oxoheptanoate;

(10S)-Juvenile hormone III diol;

4-Coumarylalcohol;

Propofol;

Fenothiocarb sulfoxide;

Hymexazol O-glucoside;

Citiolone;

2-Methyl-6-oxohepta-2,4-dienal;

1,3-Dihydro-(2H)-indol-2-one;

Formylisoglutamine;

Limonene-1,2-diol;

Butyl acrylate;

3-Hydroxycyclohexanone;

Chavicol;

(+)-Bornane-2,5-dione;

5-Chloro-1-dihydro-1-(4-piperidinyl)-2H-benzomidezole-2-one;

Carvone;

alpha-(Methylenecyclopropyl)glycine;

2,4,6-Trimethylphenol;

2-Phenyl-4-pentenal;

(E,E)-2,4-Octadienal;

Cyclohexaneacetic acid;

1,6,6-Trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one;

Butylparaben;

Eglumetad;

alpha-Curcumene;

1-Methylxanthine;

2,6-Dihydroxynicotinate;

D-Arginine;

O-ureido-L-serine;

Paracetamol sulfate;

2,5-Dimethyl-4-ethoxy-3(2H)-furanone;

D-threo-Isocitric acid;

Phenobarbital;

Protoveratrine A;

(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid;

3,5-Dihydroxy-phenylglycine;

3,4-Dihydroxybenzenesulfonic acid;

Docosahexaenoic acid ethyl ester;

Laninamivir;

Octylamine;

Ethanal tetramer;

Ureidoisobutyric acid;

Glutaconic acid;

4-Hydroxy-3-methoxy-cinnamoylglycine;

D-Phenylalanine;

4-(2-Hydroxyethyl)phenyl hydrogen sulfate;

Dopamine3-O-sulfate;

2-[(2Z)-2-({4-[(3-Aminopropyl)amino]butyl}imino)-2-hydroxyethyl]-2-hydroxysuccinic acid;

N-Formyl-L-aspartate;

Valerenic acid;

Hydroxyphenylacetylglycine;

(±)-2,2'-Iminobispropanoic acid;

Lancerin;

4-Hydroxy-3-nitrosobenzamide;

Piperidine;

3-Feruloylquinic acid;

N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonine;

Cuauhtemone;

Theogallin;

N-[(2S)-2-Hydroxypropanoyl]methionine;

Dethiobiotin;

[FAhydroxy(4:0)]N-(3S-hydroxy-butanoyl)-homoserinelactone;

2-Hydroxy-5-[(5-oxotetrahydro-2-furanyl)methyl]phenyl hydrogen sulfate;

Fumaricacid;

(4S)-4,6-Dihydroxy-2,5-dioxohexanoate;

N-Acetyl-L-methionine;

Indoxyl glucuronide;

p-Octopamine;

5-Acetylamino-6-formylamino-3-methyluracil;

D-chiro-Inositol;

Phenyl sulfoxide;

Tetrahydrodipicolinate;

L-Tyrosinemethylester;

1-Phenyl-1,2-propanedione;

3-Mercapto-3-methyl-1-butanol;

Chloroxylenol;

1-Naphthol;

Vanilloside;

(E)-4-hydroxyphenylacetaldehydeoxime;

Thymol Sulfate;

2-Methoxyacetaminophen sulfate;

Acetaminophen glucuronide;