Study M736
Study name | Kamoun N 2021 |
Title | Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain |
Overall design | The aim of this study was to evaluate the potential action of etifoxine in the relief of both somatosensory and affective consequences of neuropathic pain. C57BL6J mice were divided into the following 4 groups: (1) control group, (2) cuff group (neuropathic pain model), (3) cuff + vehicle group (neuropathic pain model plus vehicle treatment), and (4) cuff + etifoxine group (neuropathic pain model plus etifoxine treatment at the dose of 50 mg/kg). Animals received etifoxine daily injections over 5 consecutive days, 15 days after cuff surgery. The monoamine profile in the brainstem was detected using LC-MS 2 weeks after surgery, i.e. when allodynia was present but before etifoxine treatment, and after 8 weeks, when anxiodepressive symptoms had developed in cuff animals (n = 4-8 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 23 |
Tissue | Central; Brain; Brainstem; |
Platform | MS-based; LC-MS: Dionex Ultimate 3000 HPLC system coupled to a triple quadrupole mass spectrometer (Thermo Electron, San Jose, USA); |
PMID | |
DOI | |
Citation | Kamoun N, Gazzo G, Goumon Y, et al. Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain. Neuropharmacology. 2021 Jan;182:108407. |
Metabolite |
