Study M734
Study name | Jung J 2021 |
Title | Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression |
Overall design | In this study, the authors used a combination of specific acupoints, called liver-tonifying acupuncture points (KI10, LR8, LU8, LR4; AP) in Sa-am acupuncture, commonly used for treating psychological conditions. Then, they evaluated the effect of acupuncture treatment in the chronic restraint stress (CRS) model of depression and analyzed lipid metabolism. C57BL/6 mice were divided into the following 3 groups: (1) control group, (2) CRS group, and (3) CRS + acupuncture group (stressor plus acupuncture treatment). The CRS stress procedure lasted for 2 weeks, and acupuncture was administered for 1 week after stress. An ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS)-based lipidomics was applied to evaluate liver lipids on a large scale and determine the systemic effects of acupuncture on lipid metabolism in depression. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test |
Sample size | 20 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: ultra-performance liquid chromatography (UPLC, Waters Corp., Milford, MS, USA) combined with Triple TOF 5600 mass spectrometry (Sciex, Concord, ON, Canada); |
PMID | |
DOI | |
Citation | Jung J, Lee SM, Lee MJ, et al. Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression. Brain Behav Immun. 2021 Feb 16:S0889-1591(21)00045-3. |
Metabolite | PC(38:4); LysoPE(18:2); LysoPE(16:1); PS(38:4); TG(54:4); |
