Study M733
Study name | Song T 2021 |
Title | Repeated fluoxetine treatment induces transient and long-term astrocytic plasticity in the medial prefrontal cortex of normal adult rats |
Overall design | The aim of this study was to understand whether repeated fluoxetine treatment induces astrocytic plasticity. Sprague-Dawley rats were divided into the following 2 groups (n = 13 in each group): (1) control group, and (2) fluoxetine group (fluoxetine treatment at the dose of 10 mg/kg, i.p. for 15 days). Metabolic alterations in the medial prefrontal cortex were measured with in vivo 1H magnetic resonance spectroscopy at day 1 (d1) and day 20 (d20), respectively, after the last fluoxetine injection. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 26 |
Tissue | Central; Brain; Medial prefrontal cortex; |
Platform | MRS; MRS: 7.0 T/20-cm Bruker Biospec scanner; |
PMID | |
DOI | |
Citation | Song T, Chen W, Chen X, et al. Repeated fluoxetine treatment induces transient and long-term astrocytic plasticity in the medial prefrontal cortex of normal adult rats. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110252. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
