Study M719
Study name | Li SX 2018 |
Title | Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects |
Overall design | The aim of this study was to assess the effects of chronic unpredictable stress (CUS) on extracellular glutamate levels and GluN2B-associated signaling molecules in the mPFC. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUS group. The CUMS stress procedure lasted for 4 weeks. Microdialysis cannulas were implanted unilaterally in the right mPFC, and glutamate levels were quantified using liquid chromatography-mass spectrometry (n = 4/5 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 9 |
Tissue | Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Li SX, Han Y, Xu LZ, et al. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry. 2018;23(3):597-608. |
Metabolite |
