Study M717

Study name

Hassanzadeh P 2011

Title

The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs

Overall design

The aim of this study was to explore the implication of cannabinergic system transmission in the mechanisms of psychotropic drug action. Animals received once a day sterile 0.9% saline or drug (nortriptyline and citalopram, i.p., doses of 2.5, 5, and 10 mg/kg) for either 1 day or 28 consecutive days (n = 7/group). Animals were sacrificed 1, 5, and 12 h after the last injection of drug or vehicle. The frontal cortex, hippocampus, amygdala, olfactory bulb, and brain stem contents of anandamide and 2-arachidonoylglycerol, within the lipid extracts were determined using isotope-dilution liquid chromatography/mass spectrometry.

Study Type

Type3;

Data available

Unavailable

Organism

Rat; Wistar rat;

Categories of depression

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Not reported

Sample size

126

Tissue

Central; Brain; Amygdala;

Central; Brain; Olfactory bulb;

Central; Brain; Frontal cortex;

Central; Brain; Hippocampus;

Central; Brain; Brainstem;

Platform

MS-based; LC-MS: not reported;

PMID

21170518

DOI

10.1007/s00213-010-2120-4

Citation

Hassanzadeh P, Sina Rahimpour S. The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs. Psychopharmacology. 2011;215(1):129-41.

Metabolite

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0);

Anandamide;