Study M713
Study name | Zhu H 2020a |
Title | Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression |
Overall design | The aim of this study was to explore the long-term differences between three mouse models for depression, including chronic unpredictable mild stress (CUMS), corticosterone model, and olfactory bulbectomy models. C57BL/6 mice were divided into the following 2 groups (n = 30 in each group): (1) control group (no stress), and (2) CUMS group (a variety of unpredictable mild stressors). Behavioral tests were performed at two, three, and five weeks after model induction. 5-Hydroxytryptamine and dopamine levels were analyzed in the hippocampus of tested animals (week 3 and 5, n = 10 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Zhu H, Tao Y, Wang T, et al. Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression. Brain Behav. 2020;10(2):e01508. |
Metabolite |
