Study M711

Study name

Zheng F 2018

Title

[Effect of unpredictable chronic mild stress on gut microbiota in mice]

Overall design

The aim of this study was to study the effect of unpredictable chronic mild stress (CUMS) on gut microbiota in mice. C57BL/6 mice were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 5 weeks. The changes of neurotransmitters in hippocampus of mice were determined by LC-MS/MS.

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test, forced swimming test, tail suspension test

Sample size

24

Tissue

Central; Brain; Hippocampus;

Platform

MS-based; LC-MS: not reported;

PMID

N/A

DOI

10.3969/j.issn.1001-1978.2018.11.012

Citation

Zheng F, Zhu H, Zhou J, et al. [Effect of unpredictable chronic mild stress on gut microbiota in mice]. Chinese Pharmacological Bulletin 2018;34(11):1533-8. (Article in Chinese)

Metabolite

L-Glutamic acid;

Serotonin;

Norepinephrine;

Dopamine;