Study M710
Study name | Zhang X 2016 |
Title | Rhodioloside ameliorates depressive behavior via up-regulation of monoaminergic system activity and anti-inflammatory effect in olfactory bulbectomized rats |
Overall design | In this study, the olfactory bulbectomized model was used to investigate the antidepressant-like effect of Rhodioloside. Sprague-Dawley rats were divided into the following 5 groups (n = 8 in each group): (1) control group (sham olfactory bulbectomized rats), (2) olfactory bulbectomized group (olfactory bulbectomized rats), (3) olfactory bulbectomized + amitriptyline group (olfactory bulbectomized rats with amitriptyline treatment at the dose of 10 mg/kg), (4) olfactory bulbectomized + low dose of Rhodioloside group (olfactory bulbectomized rats with Rhodioloside treatment at the dose of 20 mg/kg), and (5) olfactory bulbectomized + high dose of Rhodioloside group (olfactory bulbectomized rats with Rhodioloside treatment at the dose of 40 mg/kg). After stress, rats were recovered for 2 weeks, and then treated for 2 weeks. The serotonin and norepinephrine levels in prefrontal cortex of rats were measured (n = 5 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 25 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; LC-MS: HPLC-MS (Waters Corp., Milford, MA, USA); |
PMID | |
DOI | |
Citation | Zhang X, Du Q, Liu C, et al. Rhodioloside ameliorates depressive behavior via up-regulation of monoaminergic system activity and anti-inflammatory effect in olfactory bulbectomized rats. Int Immunopharmacol. 2016;36:300-304. |
Metabolite |
