Study M708
Study name | Tian PJ 2019b |
Title | Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota |
Overall design | The aim of this study was to investigate the effect and probable mechanisms of CCFM687 treatment on the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6J mice were divided into the following 4 groups: (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 10 mg/kg), and (4) CUMS + CCFM687 groups (stressor plus CCFM687 treatment at the dose of 10^9 CFU). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric during the model building period. Short-chain fatty acids were extracted by diethyl ether from fresh cecal contents and qualified by GC-MS system (n = 6 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: GC-MS system (TSQ 9000, Thermo Scientific); |
PMID | |
DOI | |
Citation | Tian P, Zou R, Song L, et al. Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota. Food Funct. 2019;10(11):7588-7598. |
Metabolite |
