Study M707
Study name | Tian PJ 2019a |
Title | Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis |
Overall design | The aim of this study was to investigate the effect and probable mechanisms of psychobiotic treatments on the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6J mice were divided into the following 8 groups: (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 10 mg/kg), (4) CUMS + E41 groups (stressor plus E41 bacteria treatment at the dose of 10^9 CFU), (5) CUMS + M2CF22M7 groups (stressor plus M2CF22M7 bacteria treatment at the dose of 10^9 CFU), (6) CUMS + F45BB groups (stressor plus F45BB bacteria treatment at the dose of 10^9 CFU), (7) CUMS + S60 groups (stressor plus S60 bacteria treatment at the dose of 10^9 CFU), and (8) CUMS + H28L1 groups (stressor plus H28L1 bacteria treatment at the dose of 10^9 CFU). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric during the model building period. Short-chain fatty acids were extracted by diethyl ether from fresh cecal contents and qualified by GC-MS system (n = 6 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 48 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Tian P, Wang G, Zhao J, et al. Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis. J Nutr Biochem. 2019;66:43-51. |
Metabolite |
