Study M697
Study name | Carnevali L 2020 |
Title | Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats |
Overall design | The aim of this study was to measure the development of behavioral (passive stress coping, anhedonia) and biological (reduced hippocampal BDNF levels, HPA axis hyperactivity, body weight loss) alterations in adult female rats exposed to prolonged social isolation. Groningen rats were divided into the following 3 groups (n = 10 in each group): (1) control group (pair-housed rats), (2) social isolation group (social isolated rats), and (3) social isolation + URB694 group (stressor plus URB694 treatment, daily i.p. injection). The social isolation procedure lasted for 6 weeks, and drugs were administered during the last 4 weeks. Plasma corticosterone levels and hippocampal anandamide levels were measured using the HPLC/MS/MS analytical method. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Groningen rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 30 |
Tissue | Central; Brain; Hippocampus; Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Thermo Accela UHPLC gradient system with Thermo TSQ Quantum Max triple quadrupole mass spectrometer (Thermo, USA); |
PMID | |
DOI | |
Citation | Carnevali L, Statello R, Vacondio F, et al. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. Eur Neuropsychopharmacol. 2020;32:77-87. |
Metabolite |
