Study M695
Study name | Song YG 2021 |
Title | Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway |
Overall design | The aim of this study was to investigate the possible mechanism and related metabolism of Schisandra chinensis and wine processed Schisandra chinensis ameliorating anxiety behavior through modulating gut microbiota. Chronic unpredictable mild stress (CUMS) model was established. Sprague-Dawley rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + Schisandra chinensis group (stressor plus Schisandra chinensis extract treatment at the dose of 280 mg/kg), and (4) CUMS + wine processed Schisandra chinensis group (stressor plus wine processed Schisandra chinensis extract treatment at the dose of 280 mg/kg). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric once per day during the model building period. An untargeted UPLC/LTQ-Orbitrap MS metabolomic analysis of plasma was conducted. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Song Y, Shan B, Zeng S, et al. Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway. J Ethnopharmacol. 2021;266:113426. |
Metabolite | LysoPC(18:2); LysoPC(22:6); PC(16:0/18:1); LysoPE(0:0/20:2); LysoPE(0:0/18:1); PC(20:5/18:1); PC(20:5/20:3); PC(20:5/20:1); PC(18:3/22:6); PC(18:2/20:5); PC(18:0/18:4); PC(16:1/22:6); MG(0:0/20:5/0:0); LysoPE(22:4/0:0); 2-Arachidonoylglycerophosphoinositol; |
