Study M694
Study name | Smith GS 2021 |
Title | Neurotransmitters and neurometabolites in late-life depression: a preliminary magnetic resonance spectroscopy study at 7T |
Overall design | The aim of this study was to measure neurotransmitter and neurometabolite levels in the anterior (ACC) and posterior cingulate (PCC) of patients with late-life depression prior to and after 10-12 weeks of citalopram treatment using 7T 1H-MRS. Nine late-life depression patients (depression group) and nine nondepressed, healthy, age-matched controls (control group) underwent clinical and neuropsychological assessment and singlevoxel 7T 1H-MRS at baseline and after 10-12 weeks of citalopram treatment. The ACC and PCC Levels of GABA, glutamate, glutathione, N-acetylaspartylglutamate, N-acetylaspartate, and myo-inositol were quantified relative to total creatine. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 18 |
Tissue | Central; Brain; Posterior cingulate; Central; Brain; Anterior cingulate; |
Platform | MRS; MRS: 7T Philips Achieva scanner (Philips Healthcare, Best, The Netherlands); |
PMID | |
DOI | |
Citation | Smith GS, Oeltzschner G, Gould NF, et al. Neurotransmitters and neurometabolites in late-life depression: a preliminary magnetic resonance spectroscopy study at 7T. J Affect Disord. 2021;279:417-425. |
Metabolite |
