Study M688
Study name | Zhou XJ 2020b |
Title | Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis |
Overall design | The aim of this study was to assess the effects of Kai-Xin-San (KXS) on lipid metabolism in rats exposed to chronic and unpredictable mild stress (CUMS). Wistar rats were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) CUMS group, and (3) CUMS + Kai-Xin-San group (stressor plus Kai-Xin-San treatment at the dose of 676 mg/kg/day). The CUMS stress procedure lasted for 4 weeks, and drugs were administered for 3 weeks via intragastric once per day after stress. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 30 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1100 quaternary high-performance liquid chromatography (Agilent, EASY-nLC 1000, USA) with Q-Exactive mass spectrometer (Thermo Finnigan, Germany); |
PMID | |
DOI | |
Citation | Zhou X, Wang J, Lu Y, et al. Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis. J Ethnopharmacol. 2020;252:112615. |
Metabolite | PC(16:0/P-18:0); PC(16:0/P-18:1(11Z)); |
