Study M685
Study name | Zhang Y 2020 |
Title | Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability |
Overall design | The aim of this study was to investigate the effect of chronic social stress on the endothelial tight junction protein expression in the nucleus accumbens. Metabolomic profiling of the nucleus accumbens, prefrontal cortex, and hippocampus of social defeat-stressed (SDS) mice were performed to identify the molecular events that mediate blood-brain barrier breakdown. C57BL/6J mice were divided into the following 2 groups: (1) control group (no stress, n = 8), and (2) SDS group (social defeat stress for 10 days, n = 20). Stressed mice were divided into susceptible group (n = 11) and resilient group (n = 9) based on the social interaction test. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test, tail suspension test, sucrose preference test, forced swimming test |
Sample size | 28 |
Tissue | Central; Brain; Nucleus accumbens; Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: GCMS-QP2010 Ultra (Shimadzu, Japan) system;; MS-based; LC-MS: HPLC Triple-TOF/MS 5600 system (AB SCIEX, USA); |
PMID | |
DOI | |
Citation | Zhang Y, Lu W, Wang Z, et al. Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability. Biol Psychiatry. 2020;87(6):526-537. |
Metabolite | myo-Inositol; Citric acid; Stearic acid; Palmitic acid; L-Lactic acid; L-Alanine; L-Lysine; Hydroxykynurenine; |
