Study M678
Study name | Yuan ZY 2020 |
Title | HS-GC-IMS-Based metabonomics study of Baihe Jizihuang Tang in a rat model of chronic unpredictable mild stress |
Overall design | The aim of this study was to investigate the differences in volatile organic compounds (VOCs) obtained from the feces of a Baihe Jizihuang Tang (BHT)-treated rat depression model. Chronic unpredictable mild stress (CUMS) model of depression was established. Sprague-Dawley rats were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) CUMS group, and (3) CUMS + Baihe Jizihuang Tang group (stressor plus Baihe Jizihuang Tang treatment at the dose of 10.8 g/kg). The CUMS stress procedure lasted for 30 days, and drugs were administered via intragastric once per day during the model building period. Fecal samples were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test |
Sample size | 30 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: HS-GC-IMS instrument (FlavourSpec); |
PMID | |
DOI | |
Citation | Yuan ZY, Li J, Zhou X, et al. HS-GC-IMS-Based metabonomics study of Baihe Jizihuang Tang in a rat model of chronic unpredictable mild stress. J Chromatogr B Analyt Technol Biomed Life Sci. 2020;1148:122143. |
Metabolite | 2-Phenylethanol; Propionic acid; 1-Nonanol; Phenylacetaldehyde; |
